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  <xsd:element name="ScheduleOfInventoryCurrentAndNoncurrentTableTextBlock" id="knsa_ScheduleOfInventoryCurrentAndNoncurrentTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="InventoryCurrentAndNoncurrentNet" id="knsa_InventoryCurrentAndNoncurrentNet" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="RossMoatMember" id="knsa_RossMoatMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PharmaceuticalSegmentMember" id="knsa_PharmaceuticalSegmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="Kpl387Member" id="knsa_Kpl387Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AbiprubartMember" id="knsa_AbiprubartMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="UnallocatedResearchAndDevelopmentMember" id="knsa_UnallocatedResearchAndDevelopmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ResearchAndDevelopmentProgramsAxis" id="knsa_ResearchAndDevelopmentProgramsAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ResearchAndDevelopmentProgramsDomain" id="knsa_ResearchAndDevelopmentProgramsDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="TerritoryLicenseArcalystMember" id="knsa_TerritoryLicenseArcalystMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ArcalystMember" id="knsa_ArcalystMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="Kpl1161Member" id="knsa_Kpl1161Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="NonvestedRestrictedStockSharesActivityAndNonvestedPerformanceBasedUnitsActivityTableTextBlock" id="knsa_NonvestedRestrictedStockSharesActivityAndNonvestedPerformanceBasedUnitsActivityTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PerformanceBasedOptionMember" id="knsa_PerformanceBasedOptionMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="RsusRevenuePsusTsrPsusAndOptionAwardsMember" id="knsa_RsusRevenuePsusTsrPsusAndOptionAwardsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SanjK.PatelMember" id="knsa_SanjK.PatelMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="MichaelR.MegnaMember" id="knsa_MichaelR.MegnaMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DevelopmentPsusAndPerformanceBasedOptionsMember" id="knsa_DevelopmentPsusAndPerformanceBasedOptionsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="OutsideUnitedStatesAndUnitedKingdomMember" id="knsa_OutsideUnitedStatesAndUnitedKingdomMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="JohnPaoliniMember" id="knsa_JohnPaoliniMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="MarkRagosaMember" id="knsa_MarkRagosaMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="BarryQuartMember" id="knsa_BarryQuartMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AccruedInventoryAndManufacturingCurrent" id="knsa_AccruedInventoryAndManufacturingCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="OtherResearchAndDiscoveryRelatedArrangementsMember" id="knsa_OtherResearchAndDiscoveryRelatedArrangementsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
</xsd:schema>
